Polypeptide Helicity and Ensemble Prediction Tool


Helix-coil models have a long tradition in structural biology, and predicting the behavior of nascently helical polypeptides has many potential applications. Duke faculty have built a Bayesian parameterized model capable of predicting the folding into alpha-helix by any polypeptide based on its amino acid sequence. This model can be used to predict important properties of intrinsically disordered proteins, which have a growing list of important biological functions. It can also be used to design semi-rigid linkers in multivalent recognition proteins that are being developed as "biological" therapeutics targeting diseases such as HIV, COVID and cancer.

A team of students will work with the Office of Information Technology and faculty from Biochemistry, Statical Science, Computer Science and Biomedical Engineering to developing a web application and API to make the model available to scientists around the world.